NecroX-5 prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter.
Cardiovasc Res
; 94(2): 342-50, 2012 May 01.
Article
en En
| MEDLINE
| ID: mdl-22425903
ABSTRACT
AIMS:
Preservation of mitochondrial function is essential to limit myocardial damage in ischaemic heart disease. We examined the protective effects and mechanism of a new compound, NecroX-5, on rat heart mitochondria in a hypoxia/reoxygenation (HR) model. METHODS ANDRESULTS:
NecroX-5 reduced mitochondrial oxidative stress, prevented the collapse in mitochondrial membrane potential, improved mitochondrial oxygen consumption, and suppressed mitochondrial Ca(2+) overload during reoxygenation in an in vitro rat heart HR model. Furthermore, NecroX-5 reduced the ouabain- or histamine-induced increase in mitochondrial Ca(2+).CONCLUSION:
These findings suggest that NecroX-5 may act as a mitochondrial Ca(2+) uniporter inhibitor to protect cardiac mitochondria against HR damage.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sulfonas
/
Canales de Calcio
/
Daño por Reperfusión Miocárdica
/
Compuestos Heterocíclicos de 4 o más Anillos
/
Mitocondrias Cardíacas
/
Miocardio
/
Antioxidantes
Límite:
Animals
Idioma:
En
Revista:
Cardiovasc Res
Año:
2012
Tipo del documento:
Article