Medulloblastoma stem cells: where development and cancer cross pathways.
Pediatr Res
; 71(4 Pt 2): 516-22, 2012 Apr.
Article
en En
| MEDLINE
| ID: mdl-22430388
ABSTRACT
Brain tumors are the leading cause of childhood cancer mortality, with medulloblastoma (MB) representing the most frequent malignant tumor. The recent molecular classification of MB has reconceptualized the heterogeneity that exists within pathological subtypes by giving context to the role of key developmental signaling pathways in MB pathogenesis. The identification of cancer stem cell (CSC) populations, termed brain tumor-initiating cells (BTICs), in MB has provided novel cellular targets for the study of these aberrantly activated signaling pathways, namely, Sonic hedgehog (Shh) and Wingless (Wnt), along with the identification of novel BTIC self-renewal pathways. In this review, we discuss recent evidence for the presence of a MB stem cell that drives tumorigenesis in this malignant childhood tumor. We focus on evidence from cerebellar development, the recent identification of BTICs, the presence of activated developmental signaling pathways in MB, the role of epigenetic stem cell regulatory mechanisms, and how these developmental and epigenetic pathways may be targeted for novel therapeutic options.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pediatría
/
Células Madre Neoplásicas
/
Transducción de Señal
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Transformación Celular Neoplásica
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Neoplasias Cerebelosas
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Cerebelo
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Meduloblastoma
/
Modelos Biológicos
Tipo de estudio:
Prognostic_studies
Límite:
Child
/
Humans
Idioma:
En
Revista:
Pediatr Res
Año:
2012
Tipo del documento:
Article
País de afiliación:
Canadá