Chronic antihypertensive drug treatment decreases protein kinase C activity in platelets from SHR.
Clin Exp Hypertens A
; 12(6): 1063-75, 1990.
Article
en En
| MEDLINE
| ID: mdl-2245515
ABSTRACT
There is evidence that protein kinase C activity in platelets from adult SHR is significantly higher than this activity in age-matched WKY. In the present study, protein kinase C activity in the SHR was measured following antihypertensive drug treatment. Chronic administration of enalapril to SHR for 2 weeks decreased both systolic blood pressure and protein kinase C activity to the levels seen in the WKY. Similar results were obtained in case of chronic treatment of SHR with hydralazine or nifedipine. These results suggest that enhanced protein kinase C activity of SHR can be suppressed by lowering blood pressure by antihypertensive drugs.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ratas Endogámicas SHR
/
Plaquetas
/
Proteína Quinasa C
/
Antihipertensivos
Límite:
Animals
Idioma:
En
Revista:
Clin Exp Hypertens A
Año:
1990
Tipo del documento:
Article
País de afiliación:
Japón