Quantitative crawling wave sonoelastography of benign and malignant thyroid nodules.
Otolaryngol Head Neck Surg
; 147(2): 233-8, 2012 Aug.
Article
en En
| MEDLINE
| ID: mdl-22470158
ABSTRACT
OBJECTIVE:
The purpose of this study is to determine if crawling wave elastography, a novel sonoelastography technique, can be used to provide quantitative measurements of thyroid tissue shear velocity (a measure of tissue stiffness) and distinguish between benign and malignant thyroid nodules. STUDYDESIGN:
Diagnostic test assessment.SETTING:
Academic university. SUBJECTS ANDMETHODS:
Fresh thyroid specimens (n = 20) with 44 regions of interest were imaged ex vivo with crawling wave sonoelastography over a 9-month period in 2010 at a single institution. Using the sonoelastography technique, shear velocity estimations and contrast-to-noise ratios were calculated. The higher the shear velocity (SV) and contrast-to-noise ratio (CNR), the greater the tissue stiffness. Histological diagnosis was correlated with shear velocity and contrast-to-noise ratio values.RESULTS:
Both the shear velocity and contrast-to-noise values of papillary thyroid carcinoma (n = 10, CNR = 5.29, SV = 2.45 m/s) were significantly higher than benign nodules (n = 22, CNR = -0.41, SV = 1.90 m/s). There is a maximum sensitivity and specificity of 100% and 90.9%, respectively, for differentiating papillary thyroid carcinoma from benign nodules using contrast-to-noise ratio values. There is a maximum sensitivity and specificity of 83.3% and 72.7%, respectively, for differentiating papillary thyroid carcinoma from benign nodules using shear velocity values. Insufficient samples were obtained for comparison with other histological types.CONCLUSION:
Crawling wave sonoelastography can provide quantitative estimations of shear velocity, thereby depicting the elastic properties of thyroid nodules. The shear velocity and contrast-to-noise ratio can differentiate between benign thyroid nodules and papillary thyroid carcinoma with high specificity and sensitivity.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Nódulo Tiroideo
/
Diagnóstico por Imagen de Elasticidad
Tipo de estudio:
Diagnostic_studies
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Otolaryngol Head Neck Surg
Asunto de la revista:
OTORRINOLARINGOLOGIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos