Biologically active C-alkylated flavonoids from Dodonaea viscosa.
Arch Pharm Res
; 35(3): 431-6, 2012 Mar.
Article
en En
| MEDLINE
| ID: mdl-22477189
ABSTRACT
A new C-alkylated flavonoid (5,7-dihydroxy-3'-(4â³-acetoxy-3â³-methylbutyl)-3,6,4'-trimethoxyflavone (1), along with two known C-alkylated flavonoids (5,7-dihydroxy-3'-(3-hydroxymethylbutyl)-3,6,4'-trimethoxyflavone (2), 5,7,4'-trihydroxy-3'-(3-hyroxymethylbutyl)-3,6-dimethoxyflavone (3) and two new source C-alkylated flavonoids (5,7-dihydroxy-3'-(2-hydroxy-3-methyl-3-butenyl)-3,6,4'-trimethoxyflavone (4), 5,7,4'-trihydroxy-3,6-dimethoxy-3'-isoprenyl-flavone (5) were isolated from the aerial parts of Dodonaea viscosa. The structures of all compounds were established on the basis of 1D and 2D NMR spectroscopy and mass spectrometry. The isolated compounds were evaluated for their inhibitory effect on urease and α-chymotrypsin enzyme. All the compounds (1-5) exhibited mild inhibition against urease but remained recessive in case of α-chymotrypsin.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Flavonoides
/
Sapindaceae
/
Inhibidores Enzimáticos
Idioma:
En
Revista:
Arch Pharm Res
Año:
2012
Tipo del documento:
Article
País de afiliación:
Pakistán