Adherence to antiretroviral therapy and acceptability of planned treatment interruptions in HIV-infected children.
AIDS Behav
; 17(1): 193-202, 2013 Jan.
Article
en En
| MEDLINE
| ID: mdl-22584916
ABSTRACT
There have been no paediatric randomised trials describing the effect of planned treatment interruptions (PTIs) of antiretroviral therapy (ART) on adherence, or evaluating acceptability of such a strategy. In PENTA 11, HIV-infected children were randomised to CD4-guided PTIs (n = 53) or continuous therapy (CT, n = 56). Carers, and children if appropriate, completed questionnaires on adherence to ART and acceptability of PTIs. There was no difference in reported adherence on ART between CT and PTI groups; non-adherence (reporting missed doses over the last 3 days or marking <100 % adherence since the last clinical visit on a visual analogue scale) was 18 % (20/111) and 14 % (12/83) on carer questionnaires in the CT and PTI groups respectively (odds ratios, OR (95 % CI) = 1.04 (0.20, 5.41), χ(2) (1) = 0.003, p = 0.96). Carers in Europe/USA reported non-adherence more often (31/121, 26 %) than in Thailand (1/73, 1 %; OR (95 % CI) = 54.65 (3.68, 810.55), χ(2) (1) = 8.45, p = 0.004). The majority of families indicated they were happy to have further PTIs (carer 23/36, 64 %; children 8/13, 62 %), however many reported more clinic visits during PTI were a problem (carer 15/36, 42 %; children 6/12, 50 %).
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
2_ODS3
Problema de salud:
2_enfermedades_transmissibles
Asunto principal:
Aceptación de la Atención de Salud
/
Infecciones por VIH
/
Terapia Antirretroviral Altamente Activa
/
Antirretrovirales
/
Cumplimiento de la Medicación
Tipo de estudio:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
/
Qualitative_research
Límite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
País/Región como asunto:
America do norte
/
Asia
/
Europa
Idioma:
En
Revista:
AIDS Behav
Asunto de la revista:
CIENCIAS DO COMPORTAMENTO
/
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Año:
2013
Tipo del documento:
Article
País de afiliación:
Reino Unido