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Cell sources for cartilage repair; contribution of the mesenchymal perivascular niche.
Diaz-Flores, Lucio; Gutierrez, Ricardo; Madrid, Juan Francisco; Acosta, Elisa; Avila, Julio; Diaz-Flores, Lucio; Martin-Vasallo, Pablo.
Afiliación
  • Diaz-Flores L; Department of Pathology, Histology and Radiology, School of Medicine, La Laguna University, Canary Islands, Spain.
Front Biosci (Schol Ed) ; 4(4): 1275-94, 2012 06 01.
Article en En | MEDLINE | ID: mdl-22652871
Tissue and cell sources for cartilage repair are revised, including: 1) cartilage and subchondral bone (auto and allografts; single or multiple/mosaicplasty grafts), 2) cultured chondrocytes (autologous/ACI, characterized/CCI, matrix assisted/MAC, or allogenic), 3) adult mesenchymal stem cells (MSCs), 4) progenitor cells from perichondrium and periosteum, 5) embryonic and prenatal stem cells, 6) induced pluripotent stem cells, and 7) genetically modified cells. We consider the biological mechanisms that explain usage and possible complications, advantages and limitations, emerging technologies and possible modulations on extracellular matrix properties and on migration, proliferation, de-differentiation, re-differentiation, morphology, function and integration of the cells. The study of MSC role involve: a) identification, b) location (perivascular niche hypothesis, pericytes as progenitor cells), c) lineage (myoadipofibrogenic system: transit amplifying cells, fibroblast/myofibroblasts, chondrocytes, osteoblasts, odontoblasts, vascular smooth muscle cells and adipocytes), and d) use in cartilage repair, comprising: 1) MSCs recruited from neighbouring tissues (bone marrow stimulation, MSCs based "in situ" cartilage repair, microfracture) and 2) MSCs cultured and expanded from bone marrow, adipose tissue, synovial membrane or granulation tissue.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Endotelio Vascular / Cartílago / Nicho de Células Madre / Células Madre Mesenquimatosas Límite: Humans Idioma: En Revista: Front Biosci (Schol Ed) Asunto de la revista: BIOLOGIA Año: 2012 Tipo del documento: Article País de afiliación: España
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Endotelio Vascular / Cartílago / Nicho de Células Madre / Células Madre Mesenquimatosas Límite: Humans Idioma: En Revista: Front Biosci (Schol Ed) Asunto de la revista: BIOLOGIA Año: 2012 Tipo del documento: Article País de afiliación: España
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