HSC90 is required for nascent hepatitis C virus core protein stability in yeast cells.
FEBS Lett
; 586(16): 2318-25, 2012 Jul 30.
Article
en En
| MEDLINE
| ID: mdl-22659183
ABSTRACT
Hepatitis C virus core protein (Core) contributes to HCV pathogenicity. Here, we demonstrate that Core impairs growth in budding yeast. We identify HSP90 inhibitors as compounds that reduce intracellular Core protein level and restore yeast growth. Our results suggest that HSC90 (Hsc82) may function in the protection of the nascent Core polypeptide against degradation in yeast and the C-terminal region of Core corresponding to the organelle-interaction domain was responsible for Hsc82-dependent stability. The yeast system may be utilized to select compounds that can direct the C-terminal region to reduce the stability of Core protein.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
2_ODS3
Problema de salud:
2_enfermedades_transmissibles
Asunto principal:
Saccharomyces cerevisiae
/
Regulación Viral de la Expresión Génica
/
Proteínas del Núcleo Viral
/
Hepacivirus
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
FEBS Lett
Año:
2012
Tipo del documento:
Article
País de afiliación:
Japón