A novel splice variant of folate receptor 4 predominantly expressed in regulatory T cells.
BMC Immunol
; 13: 30, 2012 Jun 13.
Article
en En
| MEDLINE
| ID: mdl-22694797
ABSTRACT
BACKGROUND:
Regulatory T cells (Tregs) are required for proper maintenance of immunological self-tolerance and immune homeostasis. Folate receptor 4 (FR4) is expressed at high levels in transforming growth factor-beta (TGF-ß)-induced Tregs and natural Tregs. Moreover, antibody-mediated targeting of FR4 is sufficient to mediate Treg depletion.RESULTS:
In this study, we describe a novel FR4 transcript variant, FR4D3, in which exon 3 is deleted. The mRNA of FR4D3 encodes a FR4 variant truncated by 189 bp. FR4D3 was found to be predominantly expressed in CD4(+)CD25(+) Treg cells. Overexpression of FR4D3 in CD4(+)CD25(+) Treg cells in vitro stimulated proliferation, which may modulate the ability of these cells to bind and incorporate folic acid.CONCLUSIONS:
Our results suggested that high levels of FR4D3 may be critical to support the substantial proliferative capacity of Treg cells.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Empalme Alternativo
/
Linfocitos T Reguladores
/
Receptores de Superficie Celular
Límite:
Animals
Idioma:
En
Revista:
BMC Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2012
Tipo del documento:
Article