Ovine TRIM5α can restrict visna/maedi virus.
J Virol
; 86(17): 9504-9, 2012 Sep.
Article
en En
| MEDLINE
| ID: mdl-22696640
ABSTRACT
The restrictive properties of tripartite motif-containing 5 alpha (TRIM5α) from small ruminant species have not been explored. Here, we identify highly similar TRIM5α sequences in sheep and goats. Cells transduced with ovine TRIM5α effectively restricted the lentivirus visna/maedi virus DNA synthesis. Proteasome inhibition in cells transduced with ovine TRIM5α restored restricted viral DNA synthesis, suggesting a conserved mechanism of restriction. Identification of TRIM5α active molecular species may open new prophylactic strategies against lentiviral infections.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades de las Ovejas
/
Proteínas Portadoras
/
Enfermedades de las Cabras
/
Visna
/
Virus Visna-Maedi
Límite:
Animals
Idioma:
En
Revista:
J Virol
Año:
2012
Tipo del documento:
Article
País de afiliación:
España