Naphthomycins L-N, ansamycin antibiotics from Streptomyces sp. CS.
J Nat Prod
; 75(7): 1409-13, 2012 Jul 27.
Article
en En
| MEDLINE
| ID: mdl-22742732
ABSTRACT
Previous analyses of the naphthomycin biosynthetic gene cluster and a comparison with known naphthomycin-type products from Streptomyces sp. CS have suggested that new products can be found from this strain. In this study, screening by LC-MS of Streptomyces sp. CS products formed under different culture conditions revealed several unknown peaks in the product spectra of extracts derived from oatmeal medium cultures. Three new naphthomycins, naphthomycins L (1), M (2), and N (3), and the known naphthomycins A (4), E (5), and D (6) were obtained. The structures were elucidated using spectroscopic data from 1D and 2D NMR and HRESIMS experiments.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Streptomyces
/
Naftoquinonas
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Antibacterianos
/
Antifúngicos
Idioma:
En
Revista:
J Nat Prod
Año:
2012
Tipo del documento:
Article