An activator of the cAMP/PKA/CREB pathway promotes osteogenesis from human mesenchymal stem cells.
J Cell Physiol
; 228(3): 617-26, 2013 Mar.
Article
en En
| MEDLINE
| ID: mdl-22886506
ABSTRACT
Mesenchymal stem cells (MSCs) are multipotent adult stem cells capable of differentiating along the osteoblast, adipocyte, and chondrocyte lineages. Regulation of MSCs differentiation may be a useful tool for regenerative medicine and cell-based therapy. The discovery of small molecule that activates the osteogenic differentiation of MSCs could aid in the development of a new anabolic drug for osteoporosis treatment. We identified CW008, a derivative of pyrazole-pyridine, that stimulates osteoblast differentiation of human MSCs and increases bone formation in ovariectomized mice. CW008 promotes osteogenesis by activating cAMP/PKA/CREB signaling pathway and inhibiting leptin secretion. These results suggest that CW008 is an agonist of cAMP/PKA/CREB pathway in osteogenic differentiation and that application of CW008 may be useful for the treatment of bone-related diseases and for the study of bone biology.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Osteogénesis
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Pirazoles
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Piridinas
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Células Madre Mesenquimatosas
Límite:
Animals
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Female
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Humans
Idioma:
En
Revista:
J Cell Physiol
Año:
2013
Tipo del documento:
Article