[Fluorescence diagnosis of non-melanoma skin cancer]. / Hámeredetu bordaganatok fluoreszcens diagnosztikája.
Orv Hetil
; 153(34): 1334-40, 2012 Aug 26.
Article
en Hu
| MEDLINE
| ID: mdl-22913915
ABSTRACT
Photodynamic therapy involves - in dermatological practice usually exogenous - application of a photosensitizer then activation of accumulated protoporphyrin IX by light with an appropriate wavelength after a short incubation period. It is an evidence based method to treat certain non-melanoma skin cancers. During treatment when the excited protoporphyrin IX returns to base state, reactive oxygen species are formed leading to cell death in rapidly proliferating cells. Fluorescence of excited protoporphyrin IX can be used in diagnostics as well. In ultraviolet light, the photodamaged or neoplastic areas show coral red fluorescence which can clearly be distinguished from the much lower fluorescence of adjacent normal tissue. This process is suitable for exact determination of tumor margins so it can be used for planning surgical procedures or after photodynamic therapy at a follow up visit for the visualization of the therapeutic result. The present article reviews the literature of photodynamic diagnosis that is also used by the authors.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
1_ASSA2030
/
2_ODS3
/
6_ODS3_enfermedades_notrasmisibles
Problema de salud:
1_doencas_nao_transmissiveis
/
2_muertes_prematuras_enfermedades_notrasmisibles
/
6_malignant_skin_melanoma
/
6_non_melanoma_skin_cancer
/
6_skin_diseases
Asunto principal:
Fotoquimioterapia
/
Protoporfirinas
/
Neoplasias Cutáneas
/
Carcinoma Basocelular
/
Carcinoma Basoescamoso
/
Carcinoma de Células Escamosas
/
Cirugía de Mohs
/
Fármacos Fotosensibilizantes
/
Fluorescencia
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
Límite:
Humans
Idioma:
Hu
Revista:
Orv Hetil
Año:
2012
Tipo del documento:
Article