Lipid profiling of cancerous and benign gallbladder tissues by 1H NMR spectroscopy.
NMR Biomed
; 24(4): 335-42, 2011 May.
Article
en En
| MEDLINE
| ID: mdl-22945290
ABSTRACT
Qualitative and quantitative (1) H NMR analysis of lipid extracts of gallbladder tissue in chronic cholecystitis (CC, benign) (n = 14), xanthogranulomatous cholecystitis (XGC, intermediate) (n = 9) and gallbladder cancer (GBC, malignant) (n = 8) was carried out to understand the mechanisms involved in the transformation of benign gallbladder tissue to intermediate and malignant tissue. The results revealed alterations in various tissue lipid components in gallbladder in CC, XGC and GBC. The difference in the nature of lipid components in benign and malignant disease may aid in the identification of the biological pathways involved in the etiopathogenesis of GBC. This is the first study on lipid profiling of gallbladder tissue by (1) H NMR spectroscopy, and has possible implications for the development of future diagnostic approaches.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Protones
/
Espectroscopía de Resonancia Magnética
/
Metabolismo de los Lípidos
/
Vesícula Biliar
/
Neoplasias de la Vesícula Biliar
Tipo de estudio:
Qualitative_research
Límite:
Humans
Idioma:
En
Revista:
NMR Biomed
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
/
MEDICINA NUCLEAR
Año:
2011
Tipo del documento:
Article
País de afiliación:
India