Protective effects of hesperidin derivatives and their stereoisomers against advanced glycation end-products formation.
Pharm Biol
; 50(12): 1531-5, 2012 Dec.
Article
en En
| MEDLINE
| ID: mdl-22954318
ABSTRACT
CONTEXT Maillard reaction is implicated in the development of pathophysiology in age-related diseases. The search for newer Maillard reaction inhibitors is a priority among strategies to combat diabetes complications. OBJECTIVE:
To evaluate the inhibitory potential of hesperidin, its derivatives and their stereoisomers against advanced glycation end-products (AGEs) formation. MATERIALS ANDMETHODS:
Hesperidin and hesperetin were chirally separated and the inhibitory effects of 11 mixture of (2S)- and (2R)-hesperidin (1), (2S)-hesperidin (2), (2R)-hesperidin (3), 11 mixture of (S)- and (R)-hesperetin (4), (S)-hesperetin (5), (R)-hesperetin (6), and monoglucosyl hesperidin (7) [11 mixture of (2S)-glucosyl hesperidin (8) and (2R)-glucosyl hesperidin (9)] at a concentration of 1 mM on protein glycation reaction have been revealed using the newly constructed RNase A-methylglyoxal (MGO) assay for the early stage and the bovine serum albumin (BSA)-glucose assay for the late stage of Maillard reaction.RESULTS:
This study has demonstrated that hesperidin and its derivatives possessed relatively strong activity against the formation of AGEs. (S)-Hesperetin (5) possessed the highest inhibitory rate up to 57.4% in BSA-glucose assay, 38.2% in RNase A-MGO assay. DISCUSSION ANDCONCLUSION:
The new RNase A-MGO assay system could be used for the screening of AGEs inhibitors and hesperidin, and its derivatives could be promising candidate adjuvants for the treatment of diabetes complication, and age-related chronic diseases.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Productos Finales de Glicación Avanzada
/
Hesperidina
/
Hipoglucemiantes
Idioma:
En
Revista:
Pharm Biol
Año:
2012
Tipo del documento:
Article
País de afiliación:
Japón