The antihistamine diphenhydramine is extremely persistent in agricultural soil.
Sci Total Environ
; 439: 136-40, 2012 Nov 15.
Article
en En
| MEDLINE
| ID: mdl-23063919
ABSTRACT
The widely used antihistamine diphenhydramine is present in municipal biosolids, and is detected in runoff from agricultural land fertilized with biosolids. In the present study the kinetics and major pathways of diphenhydramine dissipation in a loam, sandy loam, and clay loam soil were determined in laboratory incubations. The time to dissipate 50% (DT(50)) of (14)C-diphenhydramine residues at 30 °C ranged from 88 ± 28 days in the clay loam to 335 ± 145 days in the loam soil. Mineralization of (14)C was insignificant, and diphenhydramine-N-oxide was the only detected extractable transformation product elucidated by radioisotope and HPLC-MS methods. There were no significant effects of municipal biosolids on the kinetics or pathways of removal. Overall, diphenhydramine is quite persistent in soils, and formation of non-extractable soil-bound residues is the major mechanism of diphenhydramine dissipation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
2_ODS3
Problema de salud:
2_quimicos_contaminacion
Asunto principal:
Suelo
/
Contaminantes del Suelo
/
Monitoreo del Ambiente
/
Agricultura
/
Difenhidramina
/
Antagonistas de los Receptores Histamínicos H1
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Sci Total Environ
Año:
2012
Tipo del documento:
Article