Interactions of staphylococci with osteoblasts and phagocytes in the pathogenesis of implant-associated osteomyelitis.
Int J Artif Organs
; 35(10): 713-26, 2012 Oct.
Article
en En
| MEDLINE
| ID: mdl-23080215
ABSTRACT
In spite of great advancements in the field of biomaterials and in surgical techniques, the implant of medical devices is still associated with a high risk of bacterial infection. Implant-associated osteomyelitis is a deep infection of bone around the implant. The continuous inflammatory destruction of bone tissues characterizes this serious bone infectious disease. Staphylococcus aureus and Staphylococcus epidermidis are the most prevalent etiologic agents of implant-associated infections, together with the emerging pathogen Staphylococcus lugdunensis. Various interactions between staphylococci, osteoblasts, and phagocytes occurring in the peri-prosthesis environment play a crucial role in the pathogenesis of implant-associated osteomyelitis. Here we focus on two main events internalization of staphylococci into osteoblasts, and bacterial interactions with phagocytic cells.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Osteoblastos
/
Osteomielitis
/
Fagocitos
/
Prótesis e Implantes
/
Infecciones Estafilocócicas
/
Staphylococcus
/
Infecciones Relacionadas con Prótesis
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Int J Artif Organs
Año:
2012
Tipo del documento:
Article
País de afiliación:
Italia