Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors.
Bioorg Med Chem Lett
; 23(4): 985-8, 2013 Feb 15.
Article
en En
| MEDLINE
| ID: mdl-23317570
ABSTRACT
The structure-activity relationship studies of a novel series of carboxylic acid derivatives of pyridine-carboxamides as DGAT-1 inhibitors is described. The optimization of the initial lead compound 6 based on in vitro and in vivo activity led to the discovery of key compounds 10j and 17h.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piridinas
/
Inhibidores Enzimáticos
/
Diacilglicerol O-Acetiltransferasa
/
Amidas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos
