Brucine, an indole alkaloid from Strychnos nux-vomica attenuates VEGF-induced angiogenesis via inhibiting VEGFR2 signaling pathway in vitro and in vivo.
Cancer Lett
; 332(1): 83-93, 2013 May 10.
Article
en En
| MEDLINE
| ID: mdl-23348691
ABSTRACT
In this study, we investigated the mechanism of brucine in tumor angiogenesis. We found that brucine inhibits VEGF-induced cell proliferation, chemotactic motility, and the formation of capillary-like structures in HUVECs in a dose-dependent manner. Brucine suppresses VEGF- induced p-VEGFR2 kinase activity and inhibits neovascularization in vivo. Brucine inhibits the downstream protein kinases of VEGFR2, including Src, FAK, ERK, AKT and mTOR. And further downregulates levels of VEGF, NO, IL-6, IL-8, TNF-α and IFN-γ in HUVECs. Taken together, our study suggests that brucine potently suppresses angiogenesis by targeting VEGFR2 activation and may be a viable drug candidate in anti-angiogenesis and anti-cancer therapies.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estricnina
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Transducción de Señal
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Neovascularización Fisiológica
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Inhibidores de la Angiogénesis
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Strychnos nux-vomica
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Receptor 2 de Factores de Crecimiento Endotelial Vascular
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Factor A de Crecimiento Endotelial Vascular
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Inhibidores de Proteínas Quinasas
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Células Endoteliales de la Vena Umbilical Humana
Idioma:
En
Revista:
Cancer Lett
Año:
2013
Tipo del documento:
Article
País de afiliación:
India