A randomized controlled trial of intranasal ketamine in migraine with prolonged aura.
Neurology
; 80(7): 642-7, 2013 Feb 12.
Article
en En
| MEDLINE
| ID: mdl-23365053
ABSTRACT
OBJECTIVE:
The aim of our study was to test the hypothesis that ketamine would affect aura in a randomized controlled double-blind trial, and thus to provide direct evidence for the role of glutamatergic transmission in human aura.METHODS:
We performed a double-blinded, randomized parallel-group controlled study investigating the effect of 25 mg intranasal ketamine on migraine with prolonged aura in 30 migraineurs using 2 mg intranasal midazolam as an active control. Each subject recorded data from 3 episodes of migraine.RESULTS:
Eighteen subjects completed the study. Ketamine reduced the severity (p = 0.032) but not duration of aura in this group, whereas midazolam had no effect.CONCLUSIONS:
These data provide translational evidence for the potential importance of glutamatergic mechanisms in migraine aura and offer a pharmacologic parallel between animal experimental work on cortical spreading depression and the clinical problem. CLASSIFICATION OF EVIDENCE This study provides class III evidence that intranasal ketamine is effective in reducing aura severity in patients with migraine with prolonged aura.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
1_ASSA2030
Problema de salud:
1_doencas_nao_transmissiveis
Asunto principal:
Administración Intranasal
/
Migraña con Aura
/
Analgésicos
/
Ketamina
Tipo de estudio:
Clinical_trials
/
Observational_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Neurology
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos