The individual and combined influence of ACE and ACTN3 genotypes on muscle phenotypes before and after strength training.
Scand J Med Sci Sports
; 24(4): 642-8, 2014 Aug.
Article
en En
| MEDLINE
| ID: mdl-23384112
ABSTRACT
Alternative measures of muscle size, strength, and power to those used in previous studies could help resolve the controversy surrounding associations between polymorphisms of the angiotensin-I converting enzyme (ACE) and α-actinin-3 (ACTN3) genes and skeletal muscle phenotypes, and the responses to resistance training (RT). To this end, we measured quadriceps femoris muscle volume (Vm), physiological cross-sectional area (PCSA), maximum isometric force (Ft), specific force (Ft per unit PCSA), maximum isoinertial strength (1-RM), and maximum power (Wmax ; n = 40) before and after 9-week knee extension RT in 51 previously untrained young men, who were genotyped for the ACE I/D and ACTN3 R577X polymorphisms. ACTN3 R-allele carriers had greater Vm, 1-RM, and Wmax than XX homozygotes at baseline (all P < 0.05), but responses to RT were independent of ACTN3 genotype (all P > 0.05). Muscle phenotypes were independent of ACE genotype before (all P > 0.05) and after RT (all P > 0.01). However, people with the "optimal" ACE+ACTN3 genotype combination had greater baseline 1-RM and Wmax compared to those with the "suboptimal" profile (both P < 0.0125). We show for the first time that the ACTN3 R577X polymorphism is associated with human Vm and (independently and in combination with the ACE I/D polymorphism) influences 1-RM and Wmax.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Actinina
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Peptidil-Dipeptidasa A
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Músculo Cuádriceps
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Fuerza Muscular
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Entrenamiento de Fuerza
Límite:
Adolescent
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Adult
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Humans
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Male
Idioma:
En
Revista:
Scand J Med Sci Sports
Asunto de la revista:
MEDICINA ESPORTIVA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Reino Unido