Plasma amyloid-ß in patients with Tangier disease.
J Alzheimers Dis
; 35(2): 307-12, 2013.
Article
en En
| MEDLINE
| ID: mdl-23388172
ABSTRACT
Tangier disease (TD) is a rare genetic disorder caused by mutations in the ATP-binding cassette transporter A1 (ABCA1) gene, which results in impaired cellular cholesterol efflux and high-density lipoprotein cholesterol deficiency. Animal and in vitro studies indicate that ABCA1 is involved in the production of amyloid-ß (Aß), a pivotal protein in Alzheimer's disease. We here examined whether plasma Aß levels are altered in TD patients. Plasma from 5 TD patients and 5 controls were analyzed for Aß1-40, Aß1-42, AßX-40, and AßX-42 but no differences were found. In conclusion, loss of ABCA1 function may not have any profound effect on Aß metabolism in humans, at least not in the periphery, as reflected by plasma Aß levels.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Tangier
/
Péptidos beta-Amiloides
Límite:
Adult
/
Aged
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Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Alzheimers Dis
Asunto de la revista:
GERIATRIA
/
NEUROLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Suecia