A comparison of buccal midazolam and intravenous diazepam for the acute treatment of seizures in children.
Iran J Pediatr
; 22(3): 303-8, 2012 Sep.
Article
en En
| MEDLINE
| ID: mdl-23399743
ABSTRACT
OBJECTIVE:
The purpose of the present study is to compare efficacy and safety of buccal midazolam with intravenous diazepam in control of seizures in Iranian children.METHODS:
This is a randomized clinical trial. 92 patients with acute seizures, ranging from 6 months to 14 years were randomly assigned to receive either buccal midazolam (32 cases) or intravenous diazepam (60 cases) at the emergency department of a children's hospital. The primary outcome of this study was cessation of visible seizure activity within 5 minutes from administration of the first dosage. The second dosage was used in case the seizure remained uncontrolled 5 minutes after the first one.FINDINGS:
In the midazolam group, 22 (68.8%) patients were relieved from seizures in 10 minutes. Meanwhile, diazepam controlled the episodes of 42 (70%) patients within 10 minutes. The difference was, however, not statistically significant (P=0.9). The mean time required to control the convulsive episodes after administration of medications was not statistically significant (P=0.09). No significant side effects were observed in either group. Nevertheless, the risk of respiratory failure in intravenous diazepam is greater than in buccal midazolam.CONCLUSION:
Buccal midazolam is as effective as and safer than intravenous diazepam in control of seizures.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Tipo de estudio:
Clinical_trials
Idioma:
En
Revista:
Iran J Pediatr
Año:
2012
Tipo del documento:
Article
País de afiliación:
Irán