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Ion exclusion chromatography of aromatic acids.
Mansour, Fotouh R; Kirkpatrick, Christine L; Danielson, Neil D.
Afiliación
  • Mansour FR; Department of Pharmaceutical Analytical Chemistry, Tanta University, Egypt.
J Chromatogr Sci ; 51(7): 655-65, 2013 Aug.
Article en En | MEDLINE | ID: mdl-23420808
ABSTRACT
The determination of aromatic acids by ion exclusion chromatography is challenging due to peak tailing and the long retention time of hydrophobic solutes. This review discusses the retention mechanisms and the factors affecting retention, eluents and detection methods used in ion exclusion chromatography of aromatic acids such as mono-, di-, tri- and tetra-carboxylic acids, amino acids, sulfonates and phenol. In addition, the different approaches used to improve the chromatographic separation of these compounds are also discussed. These approaches include introducing an internal gradient of the ionic strength, using vacancy ion exclusion chromatography, employing a hydrophilic cation exchange resin or adding a modifier such as heptanol to the dilute sulfuric acid mobile phase. The applications of these methods in the analysis of aromatic acids are provided with a table summarizing the stationary phases, the mobile phases and the detection methods.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos / Cromatografía por Intercambio Iónico Idioma: En Revista: J Chromatogr Sci Año: 2013 Tipo del documento: Article País de afiliación: Egipto

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos / Cromatografía por Intercambio Iónico Idioma: En Revista: J Chromatogr Sci Año: 2013 Tipo del documento: Article País de afiliación: Egipto
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