Molecular guided therapy for advanced pancreatic cancer patients with PI3K activated mutation: vision or illusion?
Onco Targets Ther
; 6: 95-7, 2013.
Article
en En
| MEDLINE
| ID: mdl-23450148
ABSTRACT
Despite a modern validated regimen of chemotherapy, advanced pancreatic adenocarcinoma remains the fourth most common cause of cancer-related death worldwide. The phosphoinositide 3-kinase pathway (PI3K)/Akt/mammalian target of rapamycin (mTOR) is a major signaling pathway that may be activated in advanced pancreatic cancer. To highlight the potential interest of this targetable pathway in selected advanced pancreatic cancer patients, we report herein a patient with an activated PI3K mutation who was treated in a phase I trial evaluating a treatment combination including an mTOR inhibitor.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Onco Targets Ther
Año:
2013
Tipo del documento:
Article
País de afiliación:
Francia