Transforming growth factor ß family members in regulation of vascular function: in the light of vascular conditional knockouts.
Exp Cell Res
; 319(9): 1264-70, 2013 May 15.
Article
en En
| MEDLINE
| ID: mdl-23454603
ABSTRACT
Blood vessels are composed of endothelial cells, mural cells (smooth muscle cells and pericytes) and their shared basement membrane. During embryonic development a multitude of signaling components orchestrate the formation of new vessels. The process is highly dependent on correct dosage, spacing and timing of these signaling molecules. As vessels mature some cascades remain active, albeit at very low levels, and may be reactivated upon demand. Members of the Transforming growth factor ß (TGF-ß) protein family are strongly engaged in developmental angiogenesis but are also regulators of vascular integrity in the adult. In humans various genetic alterations within this protein family cause vascular disorders, involving disintegration of vascular integrity. Here we summarize and discuss recent data gathered from conditional and endothelial cell specific genetic loss-of-function of members of the TGF-ß family in the mouse.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas de la Superfamilia TGF-beta
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Exp Cell Res
Año:
2013
Tipo del documento:
Article
País de afiliación:
Suecia