Adrenal insufficiency and adrenal replacement therapy. Current status in Spain.
Endocrinol Nutr
; 60(3): 136-43, 2013 Mar.
Article
en En, Es
| MEDLINE
| ID: mdl-23462703
ABSTRACT
Adrenal insufficiency (AI) is a rare endocrine disease, associated to increased mortality if left untreated. It can be due to a primary failure of the adrenal glands (primary AI) or malfunctioning of the hypothalamic-pituitary-adrenal axis (HPA) (secondary AI). The lack of data on incidence/prevalence of adrenal insufficiency in Spain complicates any evaluation of the magnitude of the problem in our country. Initial symptoms are non-specific, so often there is a delay in diagnosis. Current therapy with available glucocorticoids is associated with decreased quality of life in patients with treated AI, as well as with increased mortality and morbidity, probably related to both over-treatment and lack of hydrocortisone, associated with non-physiological peaks and troughs of the drug over the 24 hours. The availability of a new drug with a modified dual release (immediate and retarded), that requires one only daily dose, improves and simplifies the treatment, increases compliance as well as quality of life, morbidity and possibly mortality. This revision deals with the knowledge on the situation both globally and in Spain, prior to the availability of this new drug.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Corticoesteroides
/
Insuficiencia Suprarrenal
/
Terapia de Reemplazo de Hormonas
Tipo de estudio:
Guideline
/
Risk_factors_studies
Aspecto:
Patient_preference
Límite:
Humans
País/Región como asunto:
Europa
Idioma:
En
/
Es
Revista:
Endocrinol Nutr
Asunto de la revista:
CIENCIAS DA NUTRICAO
/
ENDOCRINOLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
España