Differential expression of CXCL1, CXCL9, CXCL10 and CXCL12 chemokines in alopecia areata.
Iran J Immunol
; 10(1): 40-6, 2013 Mar.
Article
en En
| MEDLINE
| ID: mdl-23502337
ABSTRACT
BACKGROUND:
Alopecia Areata (AA) is a non-scarring, autoimmune disorder which causes hair loss. Inflammatory reactions are involved in hair loss of the scalp and/or body. The involvement of chemokine receptors in the pathogenesis of AA is well defined among which, CXCL1 acts on neutrophils and CXCL9, CXCL10 and CXCL12 serve as T lymphocytes recruiters.OBJECTIVE:
To study the serum levels of ELR+ and ELR- CXCL1, CXCL9, CXCL10 and CXCL12 in the patients suffering from AA and healthy controls.METHODS:
The study population consisted of 30 patients suffering from AA and 30 healthy controls. Serum concentrations of CXCL1, CXCL9, CXCL10 and CXCL12 were measured using enzyme-linked immunosorbent assay (ELISA).RESULTS:
Current results showed that AA patients had significantly elevated serum levels of CXCL9 and CXCL10 in comparison to controls (p<0.001). These results also demonstrated that serum levels of CXCL1 and CXCL12 were significantly decreased in AA patients compared to control (p<0.001).CONCLUSION:
CXCL9 and CXCL10 are elevated in the AA patients and may be involved in the recruitment of T lymphocytes to the inflamed tissues. Moreover, due to the significant role played by these chemokines in angiogenesis/angiostatis phenomenon they could be considered as useful biomarkers in AA diagnosis and therapy.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfocitos T
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Alopecia Areata
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Quimiocina CXCL1
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Quimiocina CXCL9
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Quimiocina CXCL10
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Quimiocina CXCL12
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Neutrófilos
Tipo de estudio:
Diagnostic_studies
Límite:
Adolescent
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Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Iran J Immunol
Año:
2013
Tipo del documento:
Article