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Chemopreventive effect of sarcophine-diol on NOR-1-induced TPA-promoted skin carcinogenesis in female HOS:HR-1 mice.
Szymanski, Pawel T; Ahmed, Safwat A; Khalifa, Sherief; Tokuda, Harukuni; Ichiishi, Eiichiro; Iida, Akira; Suzuki, Nobutaka; Fahmy, Hesham.
Afiliación
  • Szymanski PT; Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, Brookings, SD 57007, USA.
Nat Prod Commun ; 8(2): 153-4, 2013 Feb.
Article en En | MEDLINE | ID: mdl-23513714
The cancer chemopreventive potential of sarcophine-diol in a chemical carcinogen initiation-promotion experimental tumor model in mice was evaluated. Sarcophine-diol, when given orally, afforded significant protection in the mouse skin cancer model initiated by the topical administration of (+/-)-(E)-4-methyl-2-[(E)-hydroxyamino]-5-nitro-6-methoxy-3-hexanamide (NOR-1) and promoted by 12-O-tetradecanoylphorbol-13-acetate (TPA). These findings, along with our initial reports, suggest that sarcophine-diol is an effective cancer chemopreventive agent, even when administered orally and at a very low dose and thus indicating possible potential human applications in the control of malignancy.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Anticarcinógenos / Diterpenos / Hidroxilaminas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nat Prod Commun Asunto de la revista: BOTANICA / FARMACOLOGIA / QUIMICA Año: 2013 Tipo del documento: Article País de afiliación: Estados Unidos
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Anticarcinógenos / Diterpenos / Hidroxilaminas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nat Prod Commun Asunto de la revista: BOTANICA / FARMACOLOGIA / QUIMICA Año: 2013 Tipo del documento: Article País de afiliación: Estados Unidos
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