Clarithromycin treatment in preterm infants: a pilot study for prevention of feeding intolerance.
J Matern Fetal Neonatal Med
; 26(15): 1528-31, 2013 Oct.
Article
en En
| MEDLINE
| ID: mdl-23570248
ABSTRACT
OBJECTIVE:
To compare the effectiveness of oral clarithromycin versus placebo treatment in preventing feeding intolerance in very low birth weight (VLBW) infants. STUDYDESIGN:
A prospective, randomised controlled trial in which two groups of preterm infants (birth weight <1500 g) were randomised to clarithromycin (7.5 mg/kg/dose every 12 h) or placebo treatment. During the period, 38 infants, whose parents accepted participation, were enrolled in the study. Feeding intolerance and time to achieve full enteral feeding were considered as primary outcome measures.RESULTS:
Feeding intolerance was significantly longer in placebo than clarithromycin (p = 0.031). Time to achieve full feeding after beginning the treatment was equal among the groups.CONCLUSION:
This is the first randomised controlled study of clarithromycin and placebo treatment that compares the improvement of feeding intolerance in VLBW infants. Our findings indicate a dramatic improvement in feeding intolerance after oral clarithromycin treatment. But according to our results, clarithromycin-treated infants were not able to attain full enteral feeding more quickly than placebo. This may be due to prophylactic usage of clarithromycin. Significant differences might have resulted if only infants who had feeding intolerance were recruited.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_diarrhea
Asunto principal:
Recien Nacido Prematuro
/
Claritromicina
/
Enfermedades Gastrointestinales
/
Enfermedades del Prematuro
Tipo de estudio:
Clinical_trials
Límite:
Female
/
Humans
/
Male
/
Newborn
Idioma:
En
Revista:
J Matern Fetal Neonatal Med
Asunto de la revista:
OBSTETRICIA
/
PERINATOLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Turquía