Illuminating regeneration: noninvasive imaging of disease progression in muscular dystrophy.
J Clin Invest
; 123(5): 1931-4, 2013 May.
Article
en En
| MEDLINE
| ID: mdl-23619358
ABSTRACT
Muscular dystrophies are characterized by progressive muscle weakness and wasting. Among the key obstacles to the development of therapies is the absence of an assay to monitor disease progression in live animals. In this issue of the JCI, Maguire and colleagues use noninvasive bioluminescence imaging to monitor luciferase activity in mice expressing an inducible luciferase reporter gene in satellite cells. These cells proliferate in response to degeneration, therefore increasing the level of luciferase expression in dystrophic muscle.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Mediciones Luminiscentes
/
Distrofias Musculares
Límite:
Animals
Idioma:
En
Revista:
J Clin Invest
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos