In vitro and in vivo activities of dicationic diguanidino compounds against Echinococcus multilocularis metacestodes.
Antimicrob Agents Chemother
; 57(8): 3829-35, 2013 Aug.
Article
en En
| MEDLINE
| ID: mdl-23716058
ABSTRACT
Alveolar echinococcosis (AE) is a disease predominantly affecting the liver, with metacestodes (larvae) of the tapeworm Echinococcus multilocularis proliferating and exhibiting tumor-like infiltrative growth. For many years, chemotherapeutical treatment against alveolar echinococcosis has relied on the benzimidazoles albendazole and mebendazole, which require long treatment durations and exhibit parasitostatic rather than parasiticidal efficacy. Although benzimidazoles have been and still are beneficial for the patients, there is clearly a demand for alternative and more efficient treatment options. Aromatic dications, more precisely a small panel of di-N-aryl-diguanidino compounds, were screened for efficacy against E. multilocularis metacestodes in vitro. Only those with a thiophene core group were active against metacestodes, while furans were not. The most active compound, DB1127, was further investigated in terms of in vivo efficacy in mice experimentally infected with E. multilocularis metacestodes. This diguanidino compound was effective against AE when administered intraperitoneally but not when applied orally. Thus, thiophene-diguanidino derivatives with improved bioavailability when administered orally could lead to treatment options against AE.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_helminthiasis
/
3_neglected_diseases
/
3_zoonosis
Asunto principal:
Tiofenos
/
Echinococcus multilocularis
/
Guanidinas
/
Anticestodos
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2013
Tipo del documento:
Article
País de afiliación:
Suiza