Tet1 regulates adult hippocampal neurogenesis and cognition.
Cell Stem Cell
; 13(2): 237-45, 2013 Aug 01.
Article
en En
| MEDLINE
| ID: mdl-23770080
ABSTRACT
DNA hydroxylation catalyzed by Tet dioxygenases occurs abundantly in embryonic stem cells and neurons in mammals. However, its biological function in vivo is largely unknown. Here, we demonstrate that Tet1 plays an important role in regulating neural progenitor cell proliferation in adult mouse brain. Mice lacking Tet1 exhibit impaired hippocampal neurogenesis accompanied by poor learning and memory. In adult neural progenitor cells deficient in Tet1, a cohort of genes involved in progenitor proliferation were hypermethylated and downregulated. Our results indicate that Tet1 is positively involved in the epigenetic regulation of neural progenitor cell proliferation in the adult brain.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Envejecimiento
/
Proteínas Proto-Oncogénicas
/
Cognición
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Proteínas de Unión al ADN
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Neurogénesis
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Hipocampo
Límite:
Animals
Idioma:
En
Revista:
Cell Stem Cell
Año:
2013
Tipo del documento:
Article
País de afiliación:
China