Correlation between subjective evaluation of symptoms and objective findings in early recurrent head and neck squamous cell carcinoma.
JAMA Otolaryngol Head Neck Surg
; 139(7): 687-93, 2013 Jul.
Article
en En
| MEDLINE
| ID: mdl-23788001
ABSTRACT
IMPORTANCE This study addresses the value of patients' reported symptoms as markers of tumor recurrence after definitive therapy for head and neck squamous cell carcinoma. OBJECTIVE:
To evaluate the correlation between patients' symptoms and objective findings in the diagnosis of local and/or regional recurrences of head and neck squamous cell carcinomas in the first 2 years of follow-up.DESIGN:
Retrospective single-institution study of a prospectively collected database.SETTING:
Regional hospital.PARTICIPANTS:
We reviewed the clinical records of patients treated for oral cavity, oropharyngeal, laryngeal, and hypopharyngeal carcinomas between January 1, 2008, and December 31, 2009, with a minimum follow-up of 2 years. MAIN OUTCOMES ANDMEASURES:
Correlation between symptoms and oncologic status (recurrence vs remission) in the posttreatment period.RESULTS:
Of the 101 patients included, 30 had recurrences. Pain, odynophagia, and dysphonia were independently correlated with recurrence (odds ratios, 16.07, 11.20, and 5.90, respectively; P < .001). New-onset symptoms had the best correlation with recurrences. Correlation was better between 6 to 12 and 18 to 21 months after therapy and in patients initially treated unimodally (P < .05). Primary stage and tumor site had no effect. CONCLUSIONS AND RELEVANCE The correlation between symptoms and oncologic status is low during substantial periods within the first 2 years of follow-up. New-onset symptoms, especially pain, odynophagia, or dysphonia, better correlate with tumor recurrence, especially in patients treated unimodally.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carcinoma de Células Escamosas
/
Neoplasias de Cabeza y Cuello
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Recurrencia Local de Neoplasia
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
JAMA Otolaryngol Head Neck Surg
Año:
2013
Tipo del documento:
Article
País de afiliación:
Suiza