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Anti-leukaemic activity of a novel haploidentical-transplantation approach employing unmanipulated bone marrow followed by CD6-depleted peripheral blood stem cells in children with refractory/relapsed acute leukaemia.
Schuster, Friedhelm R; Meisel, Roland; Führer, Monika; Reuther, Susanne; Hauer, Julia; Tischer, Johanna; Feuchtinger, Tobias; Laws, Hans-Jürgen; Kolb, Hans-Jochem; Borkhardt, Arndt.
Afiliación
  • Schuster FR; Clinic of Paediatric Oncology, Haematology and Clinical Immunology, Centre for Child and Adolescent Health, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Br J Haematol ; 162(6): 802-7, 2013 Sep.
Article en En | MEDLINE | ID: mdl-23829632
ABSTRACT
The treatment outcome of children with refractory acute leukaemia or relapse post-stem cell transplantation is dismal. We report 10 children (non-remission n = 7) who underwent a new haploidentical transplant approach utilizing unmanipulated bone marrow followed by CD6-depleted peripheral blood stem cells. Nine patients had successful engraftment and no evidence of leukaemia. Acute and chronic graft-versus-host-disease was observed in five and three patients, respectively; two patients died of treatment-related toxicity. Seven patients relapsed after 7 (range 3-34) months, however two patients are alive at 6·5 and 7·0 years. This approach provides anti-leukaemic activity even in heavily pre-treated children but long-term disease control requires further intervention.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre Hematopoyéticas / Leucemia / Antígenos de Diferenciación de Linfocitos T / Antígenos CD / Trasplante de Médula Ósea / Trasplante de Células Madre Hematopoyéticas Límite: Adolescent / Child / Child, preschool / Humans / Infant Idioma: En Revista: Br J Haematol Año: 2013 Tipo del documento: Article País de afiliación: Alemania

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre Hematopoyéticas / Leucemia / Antígenos de Diferenciación de Linfocitos T / Antígenos CD / Trasplante de Médula Ósea / Trasplante de Células Madre Hematopoyéticas Límite: Adolescent / Child / Child, preschool / Humans / Infant Idioma: En Revista: Br J Haematol Año: 2013 Tipo del documento: Article País de afiliación: Alemania
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