The polymorphism of CLOCK gene 3111T/C C>T is associated with susceptibility of Alzheimer disease in Chinese population.
J Investig Med
; 61(7): 1084-7, 2013 Oct.
Article
en En
| MEDLINE
| ID: mdl-23912676
ABSTRACT
OBJECTIVES:
In the present study, it was examined whether polymorphism of circadian locomotor output cycle kaput (CLOCK) gene 3111T/C was associated with susceptibility of Alzheimer disease (AD).METHODS:
This study was conducted using a case-control method. Genotypes of apolipoprotein E (APOE e4) and CLOCK gene 3111T/C were determined by restriction fragment length polymorphism method and TaqMan assay method, respectively.RESULTS:
In this study, we gathered 296 unrelated AD patients and 423 control subjects. Both in the whole sample and APOE e4 noncarriers, prevalence of C carriers in CLOCK gene 3111T/C in AD patients was significantly higher than that in control subjects (in the whole sample χ = 37.615, P < 0.0001; in APOE e4 noncarriers χ = 46.809, P < 0.0001). However, among APOE e4 carriers, prevalence of C carriers in CLOCK gene 3111T/C between patients and control subjects presents nonsignificant difference (χ = 0.812, P = 0.451).CONCLUSIONS:
Among APOE e4 noncarriers, C carriers in CLOCK gene 3111T/C were associated with a high susceptibility of AD, but among APOE e4 carriers, the functional polymorphism of CLOCK gene 3111T/C was not associated with the susceptibility of AD.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
Vigilancia de la Población
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Predisposición Genética a la Enfermedad
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Pueblo Asiatico
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Enfermedad de Alzheimer
Tipo de estudio:
Risk_factors_studies
/
Screening_studies
Límite:
Aged
/
Aged80
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Female
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Humans
/
Male
Idioma:
En
Revista:
J Investig Med
Asunto de la revista:
MEDICINA
Año:
2013
Tipo del documento:
Article