Rotenoids from Boerhaavia diffusa as potential anti-inflammatory agents.
J Nat Prod
; 76(8): 1393-8, 2013 Aug 23.
Article
en En
| MEDLINE
| ID: mdl-23914900
ABSTRACT
Five new (2, 3, 5, 7, and 9) and four known rotenoids (1, 4, 6, and 8) were isolated from a methanol extract of Boerhaavia diffusa roots. The structures of the new rotenoids were elucidated by spectroscopic data interpretation. The 70% ethanol extract, a rotenoid-rich fraction, and all isolated rotenoids were evaluated for their COX-1 and COX-2 inhibitory activities. Among the rotenoids tested, compound 7 showed the most potent COX-1 and COX-2 inhibition, with IC50 values of 21.7 ± 0.5 and 25.5 ± 0.6 µM, respectively. Boeravinone B (6) exhibited significant anti-inflammatory activity (56.6% at 50 mg/kg) when evaluated in an in vivo carrageenan-induced rat paw model.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Rotenona
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Flavonoides
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Antiinflamatorios no Esteroideos
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Nyctaginaceae
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Ciclooxigenasa 1
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Inhibidores de la Ciclooxigenasa 2
Límite:
Animals
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Nat Prod
Año:
2013
Tipo del documento:
Article
País de afiliación:
India