Retroviral infections in sheep and goats: small ruminant lentiviruses and host interaction.
Viruses
; 5(8): 2043-61, 2013 Aug 19.
Article
en En
| MEDLINE
| ID: mdl-23965529
ABSTRACT
Small ruminant lentiviruses (SRLV) are members of the Retrovirus family comprising the closely related Visna/Maedi Virus (VMV) and the Caprine Arthritis-Encephalitis Virus (CAEV), which infect sheep and goats. Both infect cells of the monocyte/macrophage lineage and cause lifelong infections. Infection by VMV and CAEV can lead to Visna/Maedi (VM) and Caprine Arthritis-Encephalitis (CAE) respectively, slow progressive inflammatory diseases primarily affecting the lungs, nervous system, joints and mammary glands. VM and CAE are distributed worldwide and develop over a period of months or years, always leading to the death of the host, with the consequent economic and welfare implications. Currently, the control of VM and CAE relies on the control of transmission and culling of infected animals. However, there is evidence that host genetics play an important role in determining Susceptibility/Resistance to SRLV infection and disease progression, but little work has been performed in small ruminants. More research is necessary to understand the host-SRLV interaction.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
1_ASSA2030
Problema de salud:
1_doencas_transmissiveis
Asunto principal:
Enfermedades de las Ovejas
/
Enfermedades de las Cabras
/
Infecciones por Lentivirus
/
Lentivirus
/
Interacciones Huésped-Patógeno
Límite:
Animals
Idioma:
En
Revista:
Viruses
Año:
2013
Tipo del documento:
Article
País de afiliación:
España