Delayed Epithelial Closure After PRK Associated With Topical Besifloxacin Use.
Cornea
; 32(10): 1365-8, 2013 Oct.
Article
en En
| MEDLINE
| ID: mdl-23974887
ABSTRACT
PURPOSE:
To report the observation of prolonged reepithelialization after photorefractive keratectomy (PRK) associated with the use of besifloxacin 0.6% (Besivance; Bausch & Lomb, Rochester, NY) underneath bandage contact lenses (BCLs) placed during surgery.METHODS:
An office-based private practice and retrospective chart review. The healing parameters examined included epithelial healing time, haze formation, discomfort, and visual recovery of 4 patients (7 eyes) treated with besifloxacin 0.6% under BCLs placed after the PRK was performed.RESULTS:
All the eyes had delayed epithelial closure (mean, 8.8 days; range 5-13 days). All the patients experienced a delayed visual recovery and significant pain after the surgery, and 2 of 4 patients experienced recurrent corneal erosions for weeks to months after they underwent the PRK. All but 1 eye developed corneal haze persisting for 1 year or more after the surgery. Only 1 eye among the 7 eyes treated with besifloxacin 0.6% under the BCL had 20/20 or better uncorrected visual acuity 3 months postoperatively.CONCLUSIONS:
All the patients treated with besifloxacin 0.6% on the stromal bed exhibited significant problems with corneal epithelial healing and delayed visual recovery. We caution the use of besifloxacin 0.6% underneath a BCL during a PRK or other ocular surface surgeries requiring corneal epithelial debridement.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Azepinas
/
Cicatrización de Heridas
/
Queratectomía Fotorrefractiva
/
Enfermedades de la Córnea
/
Fluoroquinolonas
/
Láseres de Excímeros
/
Inhibidores de Topoisomerasa II
/
Repitelización
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Cornea
Año:
2013
Tipo del documento:
Article
País de afiliación:
Marruecos