Direct and selective tagging of cysteine residues in peptides and proteins with 4-nitropyridyl lanthanide complexes.
Chem Commun (Camb)
; 49(80): 9104-6, 2013 Oct 14.
Article
en En
| MEDLINE
| ID: mdl-23989726
ABSTRACT
A cysteine-selective tagging method in water is reported, based on rapid displacement of a pyridyl nitro-substituent in simple pyridines and lanthanide complexes. The conjugation reaction creates a short link between the tag and peptide, holding the peptide closer to the Ln(3+) ion and with reduced flexibility compared to existing methods.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Péptidos
/
Piridinas
/
Proteínas
/
Cisteína
/
Elementos de la Serie de los Lantanoides
/
Complejos de Coordinación
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2013
Tipo del documento:
Article