Obstructive sleep apnea syndrome is associated with metabolic syndrome and inflammation.
Eur Arch Otorhinolaryngol
; 271(4): 825-31, 2014 Apr.
Article
en En
| MEDLINE
| ID: mdl-23995706
ABSTRACT
Obstructive sleep apnea (OSA) is an independent risk factor for cardiovascular morbidity and mortality. However, the underlying mechanism is unclear. In this cross-sectional study, we investigated the influence of OSA on metabolic syndrome (MetS) and inflammation, which were considered as cardiovascular risks. A total of 144 consecutive male patients who underwent standard polysomnography were enrolled. Fasting blood samples were obtained from all patients for glucose, high-sensitivity C-reactive protein (hs-CRP) and lipids measurement. A metabolic score was established as the total number of the positive diagnostic criteria of metabolic syndrome for each patient. Systolic blood pressure, diastolic blood pressure, fasting glucose, hs-CRP and metabolic score significantly increased with the aggravation of OSA severity. Metabolic score increased from 1.74 ± 1.20 to 2.89 ± 0.99 with OSA severity (p = 0.000). hs-CRP increased from 0.68 (0.43-1.10) to 1.44 (0.62-4.02) mg/L with OSA severity (p = 0.002). After adjustment for confounders, apnea-hypopnea index and body mass index (BMI) were the major contributing factors for metabolic score (ß = 0.257, p = 0.003 and ß = 0.344, p = 0.000, respectively), lowest O2 saturation and BMI were the independent predictors of hs-CRP (ß = -0.255, p = 0.003 and ß = 0.295, p = 0.001, respectively). OSA is independently associated with sum of metabolic components and hs-CRP.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteína C-Reactiva
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Apnea Obstructiva del Sueño
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Síndrome Metabólico
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Hiperglucemia
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Hiperlipidemias
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Hipertensión
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Inflamación
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Obesidad
Tipo de estudio:
Etiology_studies
/
Incidence_studies
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Observational_studies
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Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Eur Arch Otorhinolaryngol
Asunto de la revista:
OTORRINOLARINGOLOGIA
Año:
2014
Tipo del documento:
Article