Binding and cleavage (BINACLE) assay for the functional in vitro detection of tetanus toxin: applicability as alternative method for the safety testing of tetanus toxoids during vaccine production.
Vaccine
; 31(52): 6247-53, 2013 Dec 16.
Article
en En
| MEDLINE
| ID: mdl-24156922
Palabras clave
1,4-piperazinediethanesulfonic acid; BINACLE assay; BSA; CV; DL; EP; European Pharmacopoeia; Ganglioside GT1b; H-chain; In vitro toxicity assay; L-chain; PBS; PIPES; Synaptobrevin; TCEP; TMAO; TeNT; Tetanus neurotoxin; Toxoids; Tris(2-carboxyethyl)-phosphine hydrochloride; binding and cleavage assay; bovine serum albumin; coefficient of variation; detection limit; heavy chain; light chain; phosphate buffered saline; rSyb2; recombinant synaptobrevin-2; tetanus neurotoxin; trimethylamine-N-oxide
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Toxina Tetánica
/
Toxoides
/
Toxoide Tetánico
/
Tecnología Farmacéutica
Tipo de estudio:
Diagnostic_studies
Aspecto:
Ethics
Idioma:
En
Revista:
Vaccine
Año:
2013
Tipo del documento:
Article
