The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response.
J Exp Med
; 210(12): 2755-71, 2013 Nov 18.
Article
en En
| MEDLINE
| ID: mdl-24218137
ABSTRACT
The mechanisms involved in the maintenance of memory IgE responses are poorly understood, and the role played by germinal center (GC) IgE(+) cells in memory responses is particularly unclear. IgE(+) B cell differentiation is characterized by a transient GC phase, a bias toward the plasma cell (PC) fate, and dependence on sequential switching for the production of high-affinity IgE. We show here that IgE(+) GC B cells are unfit to undergo the conventional GC differentiation program due to impaired B cell receptor function and increased apoptosis. IgE(+) GC cells fail to populate the GC light zone and are unable to contribute to the memory and long-lived PC compartments. Furthermore, we demonstrate that direct and sequential switching are linked to distinct B cell differentiation fates direct switching generates IgE(+) GC cells, whereas sequential switching gives rise to IgE(+) PCs. We propose a comprehensive model for the generation and memory of IgE responses.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Inmunoglobulina E
/
Linfocitos B
/
Modelos Inmunológicos
/
Memoria Inmunológica
Límite:
Animals
Idioma:
En
Revista:
J Exp Med
Año:
2013
Tipo del documento:
Article