Study of the complexation of oxacillin in 1-(4-carbomethoxypyrrolidone)-terminated PAMAM dendrimers.
J Phys Chem B
; 117(47): 14865-74, 2013 Nov 27.
Article
en En
| MEDLINE
| ID: mdl-24219418
ABSTRACT
The complexation of oxacillin to three generations of 1-(4-carbomethoxypyrrolidone)-terminated PAMAM dendrimers was studied with NMR in CD3OD and CDCl3. The stochiometries, which were determined from Job plots, were found to be both solvent- and generation-dependent. The dissociation constants (K(d)) and Gibbs energies for complexation of oxacillin into the 1-(4-carbomethoxypyrrolidone)-terminated PAMAM dendrimer hosts were determined by (1)H NMR titrations and showed weaker binding of oxacillin upon increasing the size (generation) of the dendrimer.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oxacilina
/
Pirrolidinonas
/
Portadores de Fármacos
/
Dendrímeros
/
Antibacterianos
Idioma:
En
Revista:
J Phys Chem B
Asunto de la revista:
QUIMICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Dinamarca