Flagellin and F4 fimbriae have opposite effects on biofilm formation and quorum sensing in F4ac+ enterotoxigenic Escherichia coli.
Vet Microbiol
; 168(1): 148-53, 2014 Jan 10.
Article
en En
| MEDLINE
| ID: mdl-24238669
ABSTRACT
Bacteria that form biofilms are often highly resistant to antibiotics and are capable of evading the host immune system. To evaluate the role of flagellin and F4 fimbriae on biofilm formation by enterotoxigenic Escherichia coli (ETEC), we deleted the fliC (encoding the major flagellin protein) and/or the faeG (encoding the major subunit of F4 fimbriae) genes from ETEC C83902. Biofilm formation was reduced in the fliC mutant but increased in the faeG mutant, as compared with the wild-type strain. The expression of AI-2 quorum sensing associated genes was regulated in the fliC and faeG mutants, consistent with the biofilm formation of these strains. But, deleting fliC and/or faeG also inhibited AI-2 quorum sensing activity.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_neglected_diseases
/
3_zoonosis
Asunto principal:
Biopelículas
/
Proteínas de Escherichia coli
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Proteínas Fimbrias
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Percepción de Quorum
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Escherichia coli Enterotoxigénica
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Flagelina
/
Antígenos Bacterianos
Idioma:
En
Revista:
Vet Microbiol
Año:
2014
Tipo del documento:
Article