NMDA receptor-dependent long-term potentiation comprises a family of temporally overlapping forms of synaptic plasticity that are induced by different patterns of stimulation.
Philos Trans R Soc Lond B Biol Sci
; 369(1633): 20130131, 2014 Jan 05.
Article
en En
| MEDLINE
| ID: mdl-24298134
ABSTRACT
N-methyl-d-aspartate receptor (NMDAR)-dependent long-term potentiation (LTP) is extensively studied since it is believed to use the same molecular mechanisms that are required for many forms of learning and memory. Unfortunately, many controversies exist, not least the seemingly simple issue concerning the locus of expression of LTP. Here, we review our recent work and some of the extensive literature on this topic and present new data that collectively suggest that LTP can be explained, during its first few hours, by the coexistence of at least three mechanistically distinct processes that are all triggered by the synaptic activation of NMDARs.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sinapsis
/
Receptores de N-Metil-D-Aspartato
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Potenciación a Largo Plazo
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Región CA1 Hipocampal
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Modelos Neurológicos
/
Plasticidad Neuronal
Límite:
Humans
Idioma:
En
Revista:
Philos Trans R Soc Lond B Biol Sci
Año:
2014
Tipo del documento:
Article
País de afiliación:
Corea del Sur