DNA synthesis and interferon release by human peripheral lymphocytes exposed to high potassium medium.
Proc Soc Exp Biol Med
; 184(2): 133-7, 1987 Feb.
Article
en En
| MEDLINE
| ID: mdl-2433697
ABSTRACT
Lymphocytes have their membrane potential changed during transition from the resting to the active state. On these grounds, we investigated the response of human peripheral lymphocytes to a depolarizing high-potassium (102.7 mM) medium, by assaying cellular incorporation of labeled thymidine and interferon (IFN) release in the culture medium. The greatest effect is evident 3-4 days after preincubation for 120 min in high K+ medium. A temporal correlation has been observed between rate of DNA synthesis and IFN production. The IFN activity is shown to be gamma-type.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Potasio
/
Linfocitos
/
Interferones
/
Replicación del ADN
Límite:
Humans
Idioma:
En
Revista:
Proc Soc Exp Biol Med
Año:
1987
Tipo del documento:
Article