One-step radiosynthesis of 4-nitrophenyl 2-[(18) F]fluoropropionate ([(18) F]NFP); improved preparation of radiolabeled peptides for PET imaging.
J Labelled Comp Radiopharm
; 56(14): 726-30, 2013 Dec.
Article
en En
| MEDLINE
| ID: mdl-24339012
ABSTRACT
The versatile (18) F-labeled prosthetic group, 4-nitrophenyl 2-[(18) F]fluoropropionate ([(18) F]NFP), was synthesized in a single step in 45 min from 4-nitrophenyl 2-bromopropionate, with a decay corrected radiochemical yield of 26.2% ± 2.2%. Employing this improved synthesis of [(18) F]NFP, [(18) F]GalactoRGD - the current 'gold standard' tracer for imaging the expression of αV ß3 integrin - was prepared with high specific activity in 90 min and 20% decay corrected radiochemical yield from [(18) F]fluoride.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Azidas
/
Radioisótopos de Flúor
/
Radiofármacos
/
Tomografía de Emisión de Positrones
/
Marcaje Isotópico
Idioma:
En
Revista:
J Labelled Comp Radiopharm
Año:
2013
Tipo del documento:
Article
País de afiliación:
Australia