Transcriptomic microarray analysis of BoMac cells after infection with bovine foamy virus.
Arch Virol
; 159(6): 1515-9, 2014 Jun.
Article
en En
| MEDLINE
| ID: mdl-24380972
ABSTRACT
Bovine foamy virus (BFV) infections are highly prevalent among cattle worldwide. However, relatively little is known about the impact of this virus on the host immune system. In our study, we focused on a bovine macrophage cell line (BoMac) and examined changes in the BoMac transcriptome after in vitro infection with BFV using bovine BLOPlus oligo microarrays. One hundred twenty-four genes showed significant changes in expression level. The biological process categories found to be enriched include metabolic processes, cell communication, transport, immune system processes, and response to extracellular stimuli. RT-qPCR was applied to confirm the results obtained for representative genes.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Spumavirus
/
Perfilación de la Expresión Génica
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Análisis por Micromatrices
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Interacciones Huésped-Patógeno
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Macrófagos
Límite:
Animals
Idioma:
En
Revista:
Arch Virol
Año:
2014
Tipo del documento:
Article