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Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract.
Kon, Risako; Ikarashi, Nobutomo; Nagoya, Chika; Takayama, Tomoko; Kusunoki, Yoshiki; Ishii, Makoto; Ueda, Harumi; Ochiai, Wataru; Machida, Yoshiaki; Sugita, Kazuyuki; Sugiyama, Kiyoshi.
Afiliación
  • Kon R; Department of Clinical Pharmacokinetics, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
  • Ikarashi N; Department of Clinical Pharmacokinetics, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
  • Nagoya C; Department of Clinical Pharmacokinetics, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
  • Takayama T; Synthetic Medicinal Chemistry, Hoshi University, Japan.
  • Kusunoki Y; Department of Clinical Pharmacokinetics, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
  • Ishii M; Department of Clinical Pharmacokinetics, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
  • Ueda H; Department of Clinical Pharmacokinetics, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
  • Ochiai W; Department of Clinical Pharmacokinetics, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
  • Machida Y; Division of Applied Pharmaceutical Education and Research, Hoshi University, Japan.
  • Sugita K; Synthetic Medicinal Chemistry, Hoshi University, Japan.
  • Sugiyama K; Department of Clinical Pharmacokinetics, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. Electronic address: sugiyama@hoshi.ac.jp.
J Ethnopharmacol ; 152(1): 190-200, 2014 Feb 27.
Article en En | MEDLINE | ID: mdl-24412547
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 / 2_ODS3 / 3_ND Problema de salud: 1_doencas_nao_transmissiveis / 1_doencas_transmissiveis / 2_enfermedades_transmissibles / 3_diarrhea / 3_neglected_diseases Asunto principal: Rheum / Extracto de Senna / Acuaporina 3 / Laxativos Límite: Animals / Humans / Male Idioma: En Revista: J Ethnopharmacol Año: 2014 Tipo del documento: Article País de afiliación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 / 2_ODS3 / 3_ND Problema de salud: 1_doencas_nao_transmissiveis / 1_doencas_transmissiveis / 2_enfermedades_transmissibles / 3_diarrhea / 3_neglected_diseases Asunto principal: Rheum / Extracto de Senna / Acuaporina 3 / Laxativos Límite: Animals / Humans / Male Idioma: En Revista: J Ethnopharmacol Año: 2014 Tipo del documento: Article País de afiliación: Japón